Doublecortin Is a Highly Valuable Endogenous Marker of Adult Neurogenesis in Canaries

Vellema et al. [2014] report that DCXexpressing cells, based both on immunohistochemistry for the protein and in situ hybridization for the corresponding mRNA, are found throughout the canary brain, with the most pronounced expression in the telencephalon, predominantly in the mesopallium and caudal nidopallium. Based on other methods, this does indeed correspond to brain areas where an active incorporation of new neurons is observed in adult birds. The authors indicate that scattered labeled neurons were also found ‘occasionally’ in other regions outside the telencephalon (e.g. in the ventral tegmental area, the substantia nigra and the locus ceruleus). Introduction